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KMID : 0353019760130010049
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Korean Journal of Public Health
1976 Volume.13 No. 1 p.49 ~ p.56
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On the Germicidal Effect of Oral Liquid Medicine by Thermal Processing
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Abstract
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An experimental study was carried out to get optimal conditions of oral liquid medicine by thermal processing.
We made two kinds of samples which contained Thiamine·HNO₃and Niacinamide, added Bacillus subtils quantitiviely, and sterilized by autoclave; the variable conditions were time(min.) and temperature(℉).
The effectes of heating temperature and period on the medicine were as follows:
1. When thermal processing is applied on the oral liquid medicine, optimal condition which can´t degrade drug effect but destroy contaminated microrganism is 250℉ in highest heating temperature and 3 minutes in sterility time.
2. When the medicine containes natural product´s extract, optimal condition is 250℉ in temperature and 5 minutes in time.
3. When thermal processing is being held at 250℉ in temperature and 3 minutes in time, appropriate total sterility time is 30-40 minutes. On this conditions, suitable come-up time is 60%-80% of total sterility time.
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